ABSTRACT
Objective:To observe changes of adiponectin (ADPN)and heme oxygenase 1 (HO-1)levels in patients with coronary heart disease (CHD)after percutaneous coronary intervention (PCI),and correlation among ADPN ,HO-1 and oxidized low density lipoprotein (ox-LDL).Methods:A total of 60 CHD inpatients,who received PCI in our department, were regarded as CHD group,another 56 healthy subjects undergoing physical examination were regarded as healthy control group.Levels of ADPN,HO-1 and ox-LDL were measured and compared between two groups before PCI,and between before and eight weeks after PCI in CHD group.Correlation among ADPN,HO-1 and ox-LDL levels were analyzed in CHD patients.Results:Compared with healthy control group,there were significant reductions in levels of ADPN [(18.41 ±5.74)mg/L vs.(5.62±2.16)mg/L]and HO-1 [(38.71±6.95)μg/L vs.(23.87±5.28μg/L)],and significant rise in ox-LDL level [(12.56±5.94)μg/L vs.(31.25±3.95)μg/L]in CHD group before PCI,P =0.001 all.Compared with before PCI,there were significant rise in levels of ADPN [(8.49±1.95)mg/L]and HO-1 [(35.29±2.28)μg/L], and significant reduction in ox-LDL level [(16.74±2.71)μg/L]in CHD group on eight weeks after PCI,P =0.001 all. ADPN and HO-1 levels were significantly negatively correlated with ox-LDL level in CHD patients both before and after treatment (r =-0.648~-0.325,P <0.05 all).Conclusion:PCI can improve coronary blood supply,then increase levels of protectors—adiponectin and heme oxygenase 1 in CHD patients.
ABSTRACT
Objective:To observe changes of adiponectin (ADPN)and heme oxygenase 1 (HO-1)levels in patients with coronary heart disease (CHD)after percutaneous coronary intervention (PCI),and correlation among ADPN ,HO-1 and oxidized low density lipoprotein (ox-LDL).Methods:A total of 60 CHD inpatients,who received PCI in our department, were regarded as CHD group,another 56 healthy subjects undergoing physical examination were regarded as healthy control group.Levels of ADPN,HO-1 and ox-LDL were measured and compared between two groups before PCI,and between before and eight weeks after PCI in CHD group.Correlation among ADPN,HO-1 and ox-LDL levels were analyzed in CHD patients.Results:Compared with healthy control group,there were significant reductions in levels of ADPN [(18.41 ±5.74)mg/L vs.(5.62±2.16)mg/L]and HO-1 [(38.71±6.95)μg/L vs.(23.87±5.28μg/L)],and significant rise in ox-LDL level [(12.56±5.94)μg/L vs.(31.25±3.95)μg/L]in CHD group before PCI,P =0.001 all.Compared with before PCI,there were significant rise in levels of ADPN [(8.49±1.95)mg/L]and HO-1 [(35.29±2.28)μg/L], and significant reduction in ox-LDL level [(16.74±2.71)μg/L]in CHD group on eight weeks after PCI,P =0.001 all. ADPN and HO-1 levels were significantly negatively correlated with ox-LDL level in CHD patients both before and after treatment (r =-0.648~-0.325,P <0.05 all).Conclusion:PCI can improve coronary blood supply,then increase levels of protectors—adiponectin and heme oxygenase 1 in CHD patients.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of length of tibial stump on proprioceptive recovery after anterior cruciate ligament (ACL) reconstruction.</p><p><b>METHODS</b>From March 2011 to December 2011,42 patients with ACL tear were performed with reconstruction. The patients were divided randomly into three groups: group A, the patients with remained length of tibial stump ranging from 15 to 20 mm, including 8 males and 6 females, with an average age of (28.2 ± 6.6) years old; group B, the patients with remained length of tibial stump ranging from 5 to 10 mm, including 9 males and 5 females, with an average age of (27.9 ± 6.4) years old; group C, the patients with remained length of tibial stump less than 2 mm, including 9 males and 5 females, with an average age of (28.6 ± 6.8) years, old. The stability of knee were assessed by Lanchman test and anterior drawer test. The function of knee was assessed by Lysholm score and Tegner activity rating. The proprioceptive recovery was evaluated by assessing the passive reproduction of the angles with limb movement into flexion and extension in no weight bearing position.</p><p><b>RESULTS</b>Lanchman test and anterior drawer test of all patients were negative at 6 months postoperatively., and there was one case of positive outcome in each group at 12 month and 18 month postoperatively. Lysholm score and Tegner activity score of all patients at 18 month postoperatively were significantly better than that preoperatively, and there were no significant difference among three groups at 18 month postoperatively. There were no significant difference in the production of the angles at flexion to 20° and extention to 80° and 20° among these groups before and after operation. The reproduction of the angles of group A and B at flexion to 50° and extention to 50° at 6 month postoperatively were significantly better than that of group A and B preoperatively and that of group C at 6 month postoperatively, and there were no significant difference among three groups at 18 month postoperatively. The reproduction of the angles of group A and B at flexion to 80° at 12 month postoperatively were significantly better than that of group A and B preoperatively and that of group C at 12 month postoperatively, and there were no significant difference among three groups at 18 month postoperatively.</p><p><b>CONCLUSION</b>Preservation of tibial stump in ACL reconstruction has benefit in proprioceptive recovery at early stage postoperatively and the length of tibial stump should be reserved with a range from 5 to 10 mm.</p>